The official Sana news agency said the attack took place in a residential area in Palmyra, a town about 220km (140 miles) north-east of Damascus.
One activist group said a military intelligence building had been targeted and that at least 19 members of the security forces had died.
Meanwhile, heavy fighting has been reported in the east of the capital.
The local authorities closed Abbasid Square, a major roundabout, and Fares al-Khouri Street after rebel fighters attacked army roadblocks with rocket-propelled grenades and mortars, activists and witnesses said."
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